Improved Growth of Toddlers Fed a Milk Containing Synbiotics

含合生元的奶粉有助幼兒成長

Agus Firmansyah ； Pramita G Dwipoerwantoro ； Muzal Kadim ； Safira Alatas ； Nelly Conus ； Leilani Lestarina ； Florilene Bouisset ； Philippe Steenhout

《Asia Pacific Journal of Clinical Nutrition》 20卷1期 (2011/03) Pp. 69-76

https://doi.org/10.6133/apjcn.2011.20.1.11

摘要

雙歧桿菌屬的Bifidobacterium longum（BL999）、乳酸菌屬的Lactobacillus rhamonosus（LPR）、益菌助生質（菊糖和果寡糖）和長鏈不飽和脂酸（LCPUFA）被認為對健康有益。在一項隨機、雙盲控制試驗中，比較有添加合生元（BL999、LPR和益菌助生質）及長鏈不飽和脂酸的奶粉和沒有添加的奶粉，兩者對幼兒成長發育的影響。計393位健康的12個月大幼兒每天被餵食約400毫升配方奶，持續12個月。於第12、14和16個月測量體位。於第16個月檢測幼兒對痲疹和A型肝炎疫苗的反應，並於第24個月以貝氏量表評估運動、認知和行為。首要結果是第12個月到第16個月間增加的體重。次要結果是身長、頭圍和BMI的增加、腸胃道耐受性（糞便特色）、糞便中細菌量、安全性、抗疫苗IgG抗體和神經發展情形。與控制組（6.64±4.08克／天）相比，實驗組體重增加較多（7.57±4.13克／天）。兩組體重差值0.93克／天，有統計上顯著差異（p=0.025）。實驗組體重增加使得年齡別體重值的Z分數更接近世界衛生組織孩童生長標準。在第12個月和第16個月之間，實驗組的乳酸菌和腸內菌數量顯著增加。總結，添加合生元和長鏈不飽和脂酸的奶粉對幼兒成長有益處，且從乳酸菌屬總量較高，顯示對腸道菌落也有好處。

關鍵字

乳酸菌 ； 雙歧桿菌 ； 果寡醣 ； 長鏈不飽和脂酸 ； 成長

並列摘要

Bifidobacterium longum (BL999), Lactobacillus rhamonosus (LPR), prebiotics (inulin and fructo-oligosaccharides), and long-chain polyunsaturated fatty acids (LCPUFA) are believed to have health benefits. In a randomized, double-blind, controlled trial we compared growth and development of toddlers fed milk containing synbiotics (BL999, LPR, and prebiotics) and LCPUFA or a control milk. Three hundred and ninety three healthy, 12 month-old toddlers were fed approximately 400 mL/day for 12 months. Anthropometric measurements were taken at 12, 14, and 16 months. Toddlers' response to measles and hepatitis A vaccine was measured at 16 months, and Bayley scale for motor, cognitive, and behavioral functions made at 24 months. The primary outcome was weight gain between 12 and 16 months. Secondary outcomes were gain in length, head circumference, and body mass index, gastrointestinal tolerance (stool characteristics), stool bacterial counts, safety, anti-vaccine IgG, and neurodevelopment. Weight gain was greater in the synbiotics group (mean±SD, 7.57±4.13 g/day) compared with the control group (6.64±4.08 g/day). The difference of 0.93 g/day (with a 95% confidence interval of 0.12 to 1.75) is significant (p=0.025). The gain in the synbiotics group resulted in a change in z-score weight-for-age closer to WHO Child Growth Standard. There was a significant increase in lactobacilli and enterococci counts between 12 months and 16 months in the synbiotic group. We conclude that in healthy toddlers milk containing synbiotics and LCPUFA provides better growth and promotes favorable gut colonization, as shown by higher Lactobacillus counts.

並列關鍵字

lactobacillus ； bifidobacterium ； fructo-oligosaccharide ； long chain polyunsaturated fatty acids ； growth