Moderate NaFeEDTA and Ferrous Sulfate Supplementation can Improve both Hematologic Status and Oxidative Stress in Anemic Pregnant Women

EDTA铁补充能有效地改善孕妇贫血及氧化应激水平

Xiu X Han ； Yong Y Sun ； Ai G Ma ； Fang Yang ； Feng Z Zhang ； Dian C Jiang ； Yong Li

《Asia Pacific Journal of Clinical Nutrition》 20卷4期 (2011/12) Pp. 514-520

https://doi.org/10.6133/apjcn.2011.20.4.03

摘要

Iron is important general well being, to prevent or treat anemia, and is a cofactor of many enzymes in the antioxidant process. Effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate on iron bioavailability and oxidative stress in anemic pregnant women was evaluated. A 2-month randomized controlled trial was conducted on 153 anemic pregnant women, with 80≤ Hb ＜110g/L. They were randomly allocated to three groups: group C (n=51) was the placebo control group, group I (n=51) was supplemented daily with 60 mg iron as ferrous sulfate, and group IE (n=51) with 60 mg iron as NaFeEDTA. Blood samples were collected before and at the end of the intervention for measurements of hematological indices and oxidative stress parameters. Considerable increases of hematologic indicators were observed: 20.5 and 21.8 g/L for Hb (both p values ＜0.001); 4.81 and 7.19 μmol/L for plasma iron (both p values ＜0.001), 2.63 and 8.99 μg /L for ferritin (both p values ＜0.05) in I and IE groups, respectively, compared with the control group. Glutathione peroxidase (GSHPx) activities increased by 32.6 and 75.3 IU/ml, and malondialdehyde (MDA) levels decreased by 0.70 and 1.12 μmol/L in I and IE groups, compared withthe C group (p values ＜0.05). Moreover, differences of plasma iron, ferritin and GSH-Px activity were 2.38 μmol/L, 6.36 μg /L and 42.7 IU/ml were also significantly greater in the IE group than in the I group. Moderate iron supplementation may be beneficial to improving iron deficiency and oxidative stress, and NaFeEDTA is better than ferrous sulfate.

關鍵字

贫血 ； 孕妇 ； NaFeEDTA ； 硫酸亚铁 ； 氧化应激

並列摘要

Iron is important general well being, to prevent or treat anemia, and is a cofactor of many enzymes in the antioxidant process. Effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate on iron bioavailability and oxidative stress in anemic pregnant women was evaluated. A 2-month randomized controlled trial was conducted on 153 anemic pregnant women, with 80≤ Hb ＜110g/L. They were randomly allocated to three groups: group C (n=51) was the placebo control group, group I (n=51) was supplemented daily with 60 mg iron as ferrous sulfate, and group IE (n=51) with 60 mg iron as NaFeEDTA. Blood samples were collected before and at the end of the intervention for measurements of hematological indices and oxidative stress parameters. Considerable increases of hematologic indicators were observed: 20.5 and 21.8 g/L for Hb (both p values ＜0.001); 4.81 and 7.19 μmol/L for plasma iron (both p values ＜0.001), 2.63 and 8.99 μg /L for ferritin (both p values ＜0.05) in I and IE groups, respectively, compared with the control group. Glutathione peroxidase (GSHPx) activities increased by 32.6 and 75.3 IU/ml, and malondialdehyde (MDA) levels decreased by 0.70 and 1.12 μmol/L in I and IE groups, compared withthe C group (p values ＜0.05). Moreover, differences of plasma iron, ferritin and GSH-Px activity were 2.38 μmol/L, 6.36 μg /L and 42.7 IU/ml were also significantly greater in the IE group than in the I group. Moderate iron supplementation may be beneficial to improving iron deficiency and oxidative stress, and NaFeEDTA is better than ferrous sulfate.

並列關鍵字

anemia ； pregnant women ； NaFeEDTA ； ferrous sulfate ； oxidative stress