- 期刊
Effects of Vitamin A, Vitamin A plus Zinc, and Multiple Micronutrients on Anemia in Preschool Children in Chongqing, China
維生素A、維生素A 加鋅及微量营养素复合补充对中國重慶的学龄前儿童贫血及体格生长的影响
摘要
为进一步明确维生素A（VA）、VA与其他微量营养素复合补充对学龄前儿童贫血及体格生长的影响，本研究共纳入290名36-72个月的学龄前儿童，并随机分为3个强化补充组：VA组（A组）、VA加锌组（AZ组）以及VA与复合微量营养素组（AMM组）。强化补充6个月后，AZ组受试儿童的身高及身高Z评分（HAZ）增长显著高于其他两组；AMM组体重增长优于其余各组；各组受试儿童血红蛋白（Hb）及血清锌浓度均较补充前明显增加，且AMM组受试儿童Hb浓度增长显著高于其余两组。此外，AMM组血清VA、AZ组血清锌浓度增长均显著高于其他各组。3种不同强化补充方式均能促进受试儿童身高增长并降低贫血患病率。补充VA加锌对受试儿童身高及HAZ的促进作用最优；而补充VA与复合微量营养素对改善学龄前儿童Hb浓度更加有效。
並列摘要
This study is to clarify the impact of vitamin A or vitamin A combined with other micronutrients supplementation on anemia and growth in preschoolers. In the present study, a total of 290 preschoolers, aged 36-72 months old were randomly assigned to 3 treatment groups: vitamin A (A group), vitamin A plus zinc (AZ group), and vitamin A combined with additional multiple-micronutrient (AMM group). After 6-month supplementation, the height and height-for-age z-score gains of the AZ group were significantly higher than the other groups; the weight gain of the AMM group was greater than the other groups. Compared with baseline values, the concentrations of hemoglobin, and zinc at the end significantly increased in all 3 groups. The incremental concentrations of hemoglobin in the AMM group were significant higher than in the other two groups. Furthermore, the incremental concentrations of serum retinol in the AMM group, and the increase in serum zinc concentrations in the AZ group were significantly higher, respectively, than in the other groups. These 3 kinds of supplements in the present study are effective in enhancing height gains and are effective in reducing the prevalence of anemia. Supplementation of zinc plus vitamin A is a better way for improving children's height and height-for-age z-score. Vitamin A combined with multiple-micronutrient is more effective in improving the hemoglobin concentrations in preschool children.
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