Plasma ω-3 Fatty Acid Levels Negatively and ω-6 Fatty Acid Levels Positively Associated with Other Cardiovascular Risk Factors Including Homocysteine in Severe Obese Subjects

重度肥胖者其血漿ω-3和ω-6脂肪酸與其他心血管危險因子包括同半胱胺酸成負向和正向相關

Idris Mehmetoglu ； F Hümeyra Yerlikaya ； Sevil Kurban ； Hakkı Polat

《Asia Pacific Journal of Clinical Nutrition》 21卷4期 (2012/12) Pp. 519-525

https://doi.org/10.6133/apjcn.2012.21.4.07

摘要

Obesity and homocysteine (tHcy) are important risk factors for cardiovascular diseases (CVD). Plasma omega-3 fatty acids (ω-3 FAs) and omega-6 fatty acids (ω-6 FAs) are essential fatty acids with diverse biological effects in human health and disease. We have investigated the relation of plasma ω-3 FAs and ω-6 FAs levels with other cardiovascular risk factors including tHcy in severe obese subjects. This study was performed on 96 severe obese and 65 normal weight subjects. Plasma fatty acid composition was measured by GC/MS and serum tHcy level was measured by HPLC methods. There were no differences between groups in terms of concentrations of serum tHcy, plasma ω-3 FAs, ω-6 FAs and ω-3/ω-6 ratio, whereas serum vitamin B-12 (p＜0.01) and folic acid (p＜0.05) levels were lower than those of the normal weight subjects. Homocysteine positively correlated with ω-6 FAs and negatively correlated with ω-3 FAs in severe obese and normal weight subjects. Serum vitamin B-12 positively correlated with ω-3 FAs (p＜0.01) and ω-3/ω-6 ratio (p＜0.01) and negatively correlated with ω-6 FAs (p＜0.05) in severe obese subjects. Serum folic acid positively correlated with ω-3 FAs (p＜0.01) in severe obese subjects. Our results suggest an association between the plasma ω-3 FAs and ω-6 FAs and serum tHcy concentrations in severe obese and normal weight subjects. Low levels vitamin B-12 and folic acid may have been responsible for the elevated tHcy levels in severe obese subjects, increasing the risk for future development of cardiovascular diseases.

關鍵字

ω-3脂肪酸 ； ω-6脂肪酸 ； 同半胱胺酸 ； 肥胖 ； 維生素B-12

並列摘要

Obesity and homocysteine (tHcy) are important risk factors for cardiovascular diseases (CVD). Plasma omega-3 fatty acids (ω-3 FAs) and omega-6 fatty acids (ω-6 FAs) are essential fatty acids with diverse biological effects in human health and disease. We have investigated the relation of plasma ω-3 FAs and ω-6 FAs levels with other cardiovascular risk factors including tHcy in severe obese subjects. This study was performed on 96 severe obese and 65 normal weight subjects. Plasma fatty acid composition was measured by GC/MS and serum tHcy level was measured by HPLC methods. There were no differences between groups in terms of concentrations of serum tHcy, plasma ω-3 FAs, ω-6 FAs and ω-3/ω-6 ratio, whereas serum vitamin B-12 (p＜0.01) and folic acid (p＜0.05) levels were lower than those of the normal weight subjects. Homocysteine positively correlated with ω-6 FAs and negatively correlated with ω-3 FAs in severe obese and normal weight subjects. Serum vitamin B-12 positively correlated with ω-3 FAs (p＜0.01) and ω-3/ω-6 ratio (p＜0.01) and negatively correlated with ω-6 FAs (p＜0.05) in severe obese subjects. Serum folic acid positively correlated with ω-3 FAs (p＜0.01) in severe obese subjects. Our results suggest an association between the plasma ω-3 FAs and ω-6 FAs and serum tHcy concentrations in severe obese and normal weight subjects. Low levels vitamin B-12 and folic acid may have been responsible for the elevated tHcy levels in severe obese subjects, increasing the risk for future development of cardiovascular diseases.

並列關鍵字

ω-3 fatty acids ； ω-6 fatty acids ； homocysteine ； obesity ； vitamin B-12