Vitamin D and depression: mechanisms, determination and application

Chunmei Geng ； Abdul Sami Shaikh ； Wenxiu Han ； Dan Chen ； Yujin Guo ； Pei Jiang

《Asia Pacific Journal of Clinical Nutrition》 預刊文章 Pp. 1-13

https://doi.org/10.6133/apjcn.201908/PP.0004

摘要

Depression is the most common debilitating psychiatric disease, the pathological mechanisms of which are associated with multiple aspects of neural function. While recent evidence has consistently suggested that a suboptimal vitamin D status is frequently observed in patients with depression, the results concerning whether vitamin D insufficiency is a causal factor of depression or is secondary to depressive behavior are conflicting; additionally, the lack of consistency of the method of vitamin D determination between labs has further worsened this confusion. Herein, we reviewed the neuroactivity of vitamin D that may be associated with depression and the current studies and clinical investigations to provide a full overview on the use of vitamin D in the treatment and prevention of depression.

關鍵字

depression ； vitamin D ； pathological mechanisms ； neuroactivities ； determination