本研究目的是了解在沙烏地阿拉伯成人中,膳食脂肪酸的攝取,如:飽和、多元不飽和以及單元不飽和脂肪酸,是否為發炎反應的調節物質或影響促凝血。本研究檢測發炎因子像是C-反應蛋白、腫瘤壞死因子-α和活化的Ⅰ型纖溶酶原激活物抑制因子(aPAI-1)。在此橫斷面研究中,以隨機抽樣,總計232位沙烏地阿拉伯成人參與,年齡介於18到60歲之間。以獨立Student t檢定比較常態分佈資料的平均值。使用斯皮爾曼係數來確定變項間的相關。進行相關性測定之前,不同的脂肪酸和脂肪因子的數值先轉化成對數/平方根,將數據常態化,便於統計分析。統計上的顯著設定為p值小於0.05。研究結果顯示,飲食攝取的多元和單元不飽和脂肪酸與aPAI-1有顯著的正相關,但飽和脂肪酸與其則無相關。另一方面,男性飲食攝取的飽和脂肪酸顯示與血清中C-反應蛋白呈現負相關。膳食不飽和脂肪酸可能與產生促凝血因子而不增加促發炎因子的分泌有關;雖然飽和脂肪酸對aPAI-1沒有影響,但與發炎因子C-反應蛋白呈現負相關。結論是,飲食攝取脂肪酸在成年男、女性中對發炎過程的影響可能有別。需要未來進一步的研究確認目前的研究結果。
The aim of the study was to understand whether dietary fatty acids such as saturated, polyunsaturated, and monounsaturated fatty acids act as inflammatory mediators or influence pro-coagulation in Saudi adults. The study sought to examine inflammatory factors such as C-reactive protein, tumor necrosis factor-alpha and activated plasminogen activator inhibitor 1. A total number of 232 consenting Saudi adults, aged 18-60 years were randomly selected in this cross-sectional study. Independent Student t-test was done to compare means of normally distributed data. Spearman correlation between the variables was determined. The values of different fatty acids and adipokines were transformed logarithmically/square root to normalize data before correlations were determined and statistical analyses performed. Statistical significance was set at p<0.05. The results show a significant positive correlation of dietary intake of poly and monounsaturated fatty acids, but not saturated fatty acids, with activated plasminogen activator inhibitor 1 (r=0.31, p=0.02, r=0.32 p=0.04). On the other hand, dietary intake of saturated fatty acids showed a negative correlation with serum C-reactive protein levels (p=0.001) in males. Dietary unsaturated fatty acids is possibly associated with the production of a pro-coagulation factor without enhancing the secretion of pro-inflammatory molecules, while saturated fatty acids have no effect on activated plasminogen activator inhibitor 1, but their level is negatively associated with the inflammatory factor C-reactive protein. We conclude that dietary intake may exert a gender-specific effect in inflammatory processes among adults. Further studies are warranted to confirm present findings.