- 期刊
Effects of Bifidobacterium animalis lactis HN019 (DR10^(TM)), inulin, and micronutrient fortified milk on faecal DR10^(TM), immune markers, and maternal micronutrients among Indonesian pregnant women
摘要
Background and Objectives: Maternal nutrition affects fetal growth and development. This study evaluates the effects of milk powder fortified with micronutrients, docosahexaenoic acid (DHA), a prebiotic, and probiotic Bifidobacterium animalis subsp. lactis HN019 DR10^(TM) on the micronutrient status, as well as the presence of faecal probiotic and immune markers in pregnant women. Methods and Study Design: This randomised, double-blind, placebo-controlled trial was conducted at Budi Kemuliaan and Cipto Mangunkusumo Hospital in Jakarta from 2013 to 2014. A total of 104 participants were randomly allocated to receive either completely enriched milk powder (intervention group) or iron- and vitamin folic-acid-enriched milk powder (control group). Data were collected using standardised measures and were statistically analysed using the independent t or Mann-Whitney test. Results: At the baseline, the micronutrient status of the participants was acceptable, except for 25-OH-vitamin D, in both the intervention and control groups. Vitamin B-1, zinc, total free fatty acid, linoleic acid, arachidonic acid, and DHA were significantly higher in the intervention group in the second trimester (p=0.014, 0.028, 0.023, 0.014, 0.001, and 0.032, respectively). Interleukin-6 and tumor necrosis factor-α levels did not significantly vary during pregnancy. B. animalis subsp. lactis DR10^(TM) was present in the faeces of the intervention group but not the control group (61.1% vs 0%). Conclusion: Milk fortified with a prebiotic, probiotic, DHA and micronutrients increases the faecal concentration of the organism used for fortification in Indonesian pregnant women. This may represent an improvement in intra-partum maternal gut health.
關鍵字
probiotic ； micronutrient ； milk ； pregnant ； digestive health ； vitamin folic-acid ； homocysteine延伸閱讀
- Baglatzi, L., Gavrili, S., Stamouli, K., Zachaki, S., Favre, L., Pecquet, S., Benyacoub, J., & Costalos, C. (2016). Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study. Clinical Medicine Insights: Pediatrics, (2016), 11-19. https://doi.org/10.4137/CMPed.S33096
- 廖彩汝（2012）。Effects of lactic acid bacteria fermented buckwheat extracts on the antiproliferation of colon cancer cell line HT-29 and anticytotoxicity of human intestine cell line Int-407〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2012.02681
- 林淑媛、洪宗羽、林敬剛、劉訓成、林炳宏、王博、盧金鎮、周仲光（2011）。Growth Performance, Serum Lipid Trait, Intestinal Microflora and Histological Alterations of Broilers Fed Diets Contain Multi-Strain Probiotic Fermented Soybean Meal。台灣農學會報，12(5)，418-429。https://doi.org/10.6730/JAAT.201110_12(5).0002
- Gamboa, E., Broadbent, E., Quintana, N., Callaway, S., Donoso, P., Linehan, M., Wibowo, L., Santika, O., West, J. H., Hall, P. C., & Crookston, B. T. (2020). Interpersonal communication campaign promoting knowledge, attitude, intention, and consumption of iron folic acid tablets and iron rich foods among pregnant Indonesian women. Asia Pacific Journal of Clinical Nutrition, 29(3), 545-551. https://doi.org/10.6133/apjcn.202009_29(3).0013
- Gamboa, E., Broadbent, E., Quintana, N., Callaway, S., Donoso, P., Linehan, M., Wibowo, L., Santika, O., West, J. H., Hall, P. C., & Crookston, B. T. (2013). Interpersonal communication campaign promoting knowledge, attitude, intention, and consumption of iron folate acid tablets and iron rich foods among pregnant Indonesian women. Asia Pacific Journal of Clinical Nutrition, (), 1-15. https://doi.org/10.6133/apjcn.202008/PP.0004