The present study was design to examine the joint contribution of Spiritual Intelligence, Altruism, School Environment and Academic Achievement for predicting Mental Health of senior secondary school students. Total 934 students of class +1 (mean age 16.4 Years) studying in schools affiliated to Punjab School Education Board were taken as sample. Mental Health Battery (2000) developed by Singh and Sen Gupta; Spiritual Intelligence scale (2006) developed by Singh, Altruism scale (1988) developed by Rai and Singh; School Environment inventory (2002) prepared by Misra were used to collect data. Result through multiple correlation and regression analysis revealed that Type of school, Spiritual Intelligence, Altruism, rejection (dimension of School Environment) and control(dimension of School Environment) were the significant predictor of Mental Health; and gender, location of residence, creative stimulation, cognitive encouragement, acceptance, permissiveness and Academic Achievement were not significant predictors of Mental Health.