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Introduction: The co-existence multiple myeloma (MM) and another cancer have been reported severally in literature, but medullary thyroid carcinoma (MTC) as a second cancer with multiple myeloma is an extremely rare case, to our knowledge, there are no prior reports of these concurrent cancers. Case Report: A 54-year-old man was admitted with chief complain of bone pain, clinical investigation revealed, lytic bone lesions and infiltration of plasma cells in bone marrow and patient with diagnosis of multiple myeloma received chemotherapy, he was in partial remission, but nine months later a solitary nodule was founded in his thyroid, with high levels of calcitonin and fine needle aspiration (FNA) reported the medullary thyroid carcinoma, after total thyroidectomy which confirmed this cancer the patient recovered and now he is followed- up for these cancers. Conclusion: Diagnosis of secondary cancer is important because: first to distinguish secondary malignancy from metastatic cancer and then try to investigate the etiology of this association.

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