Papillary carcinoma of the thyroid generally follows an indolent course, with slow growth and a low metastatic rate. The most common sites of metastases are the cervical lymph nodes, the lungs’ and bone. Pleural metastasis is a rare condition, but a poor prognostic sign when it appears. We present a female who had a history of papillary thyroid carcinoma, and who developed massive right side pleural effusion one year after total thyroidectomy. Papillary thyroid carcinoma with pleural metastasis was considered due to elevated thyroglobulin (Tgb) in the pleural metastasis had presented.