台灣地區雙胞胎嬰兒家庭心臟血管疾病危險因子的分離分析

Segregation Analysis of Cardiovascular Disease Risk Factors in Families of Twin Infants in Taiwan

曾玟富(Wen-Fuh Tseng) ； 戴政(John-Jen Tai) ； 陳建仁(Chein-Jen Chen)

《中華民國公共衛生學會雜誌》 10卷5期 (1991/12) Pp. 321-330

https://doi.org/10.6288/JNPHARC1991-10-05-12

摘要

膽固醇、三酸甘油酯、高密度脂蛋白膽固醇、低密度脂蛋白膽固醇、血壓及肥胖都是常見的心臟血管疾病的危險因子。本研究的目的在於利用同卵雙胞胎及其父母親的各心臟血管疾病危險因子的測量值，以混合模式的假設，發展類似鑑別分析(discriminant analysis)的方法來估計遺傳率，以評估遺傳和環境作用的相對重要性。父母親及兩個同卵雙胞胎均有測量值的家庭數，因危險因子的不同而異：肥胖度有58個家庭，膽固醇有37個，三酸甘油酯36個，心縮壓43個，心舒壓47個，高密度脂蛋白膽固醇23個，低密度脂蛋白膽固醇21個。本研究所估計的遺傳率，心縮壓爲0.28，心舒壓爲0.57，高密度脂蛋白膽固醇爲0.57-0.65，低密度脂蛋白膽因醇爲0.60-0.70，血清膽固醇爲0.62，血清三酸甘油酯爲0.65-0.70，肥胖度爲0.68-0.73，此結果顯示危險因子受遺傳作用的影響很大。本研究受到樣本數少，變異數不穩定的限制，遺傳率估計值的變動也較大。

關鍵字

心臟血管疾病 ； 遺傳度 ； 混合模式 ； 鑑別分析

並列摘要

Serum cholesterol, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol, blood pressure as well as obesity are usually regarded as the major risk factors of cardiovascular diseases. The objective of this study is to develop a quantitative method for analyzing quantitative traits of monozygotic twins and their parents with an aim to estimate the heritability of the major gene based on the assumption of mixed model.
The numbers of families in which the continuous measurements of cardiovascular risk factors among two parents and their monozygotic twin children were all available varied from 21 for low density lipoprotein cholesterol to 58 for obesity. The heritability of the major gene was estimated as 0.28 for systolic blood pressure, 0.57 for diastolic blood pressure, 0.57-0.65 for high density lipoprotein cholesterol, 0.60-0.70 for low density lipoprotein cholesterol, 0.62 for cholesterol, 0.65-0.70 for triglycerides and 0.68-0.73 for obesity. The results suggest a relatively strong genetic influence on these cardiovascular disease risk factors. However, small sample size of this study may result in estimates with a large variation.

並列關鍵字

Cardiovascular Disease ； Heritability ； Mixed Model ； Discriminant Analysis