Maternal Total Serum Estriol Value in High Risk Pregnancies

高危險妊娠之母體血清全雌三醇測定研究

李家琨(C. K. Lee) ； 師明哲(M. T. Shih) ； 尹長生(C. S. Yin) ； 林士新(S. S. Lin)

《Journal of Medical Sciences》 2卷4期 (1978/07) Pp. 695-701

摘要

一九七七與一九七八年內，以放射免疫法測定三十九位各種不同高危險妊娠之血清全雌三醇作為胎盤功能及胎兒健康情況之基礎檢查，凡有問題者再以「胎動時心律加速之測定」及「催生素挑戰試驗」作進一步判斷。血清全雌三醇雖下降或持續的低值，但「胎動時心律加速之測定」及「催生素挑戰試驚」皆正常，仍不認為胎兒健康遭受嚴重威脅而作為中止妊娠之依據，若血清全雌三醇下降而「催生素挑戰試驗」中呈現晚期減速時應考慮中止妊娠以減少胎兒危險。上述高危險妊娠之周產兒死亡皆有其特殊原因，而非此種產前胎兒守護方法不佳所致。本研究可知以母親血清內全雌三醇作為基礎，再輔以「胎動時心律加速之測定」及「催生素挑戰試驗」不失為目前產前胎兒較佳之守護方法之一。

並列摘要

Maternal total serum estriol (E3) value had been routinely detected by radioimmunoassay (RIA) method at Tri-Service General Hospital since 1977 for the evaluation of fetal well-being among high risk pregnancies.A total of 39 patients with various pregnancy complications were studied. In our practice, most high risk pregnancies were managed according to the clinical course, the estriol values, and the results of fetal activity acceleration determination (F. A. D. according to C. Y. Lee), and oxytocin challenge test (O. C. T.). It is shown that the serial maternal total serum estriol determination is a useful test for screening of uteroplacental insufficiency among high risk pregnancies when correlated with the perinatal mortality.