先天性巨細胞包涵體疾病死亡之新生兒－病例報告

本文報告典型的巨細胞包涵體疾病之一男嬰，在出生時即表現低體重，肝脾腫大、黃膽、溶血性貧血、血小板減少性紫斑、小頭及腦部的損傷、新生兒及母親之巨細胞補體結合抗體均存陽性。新生兒在出生後8小時即死亡。死後的病理解剖發現肝、肺、腎、淋巴、甲狀腺及松果體均發現具包涵體的細胞及腦部多處壞死；且肺、肝組織均培養出巨細胞病毒。

關鍵字

巨細胞病毒；巨細胞包涵體疾病

並列摘要

This report describes a newborn with classical symptoms of cytomegalic inclusion disease at birth with hepatosplenomeglay, jaundice, hemolytic anemia, thrombocytopenia purpura and brain damage. The 24 years-old mother had a history of influenza-like disease at the 3 month gestation period. Complement-fixation antibody for cytomegalovirus were positive in the mother and newborn. He died on the first day of life. After the newborn's death, viral culture from the lung, liver grew cytomegalovirus. The significant histopathologic findings were inclusion-bearing cells were found in the lung, liver, kidney, lymph node, thyroid gland and pineal body as well as diffuse necrosis of the brain. We also discuss the maternal-fetal problems that can arise after infection by a cytomegalovirus.

並列關鍵字

Cytomegalovirus ； Cytomegalic inclusion disease

國際替代計量

先天性巨細胞包涵體疾病死亡之新生兒－病例報告

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