Cross-Reactive Antibody in the Opsonization of Mutant Strains of Salmonella Typhimurium

以六株具不同脂多醣成份之鼠傷寒桿菌吸附正常人血清連續依序吸附結果發現交叉反應抗體對中性白血球吞噬平滑株（S）之調理作用有促進作用，但抗平滑株抗體對粗糙株（R）之調理作用沒有影響。以間接免疫螢光抗體試驗可見抗半粗糙株（SR）抗體（IgG）亦有助於中性白血球吞噬SR株及S株。抗Ra抗體只受Ra株之吸附而不為其他細菌株所吸附。交叉反應抗體對中性白血球吞噬Rb2株沒有加強作用，但可增強中性白血球吞噬S及SR株。本實驗結果顯示交叉反應抗體可藉增強對細菌的調理作用，提供免疫保護作用，尤其是中性白血球對S株之吞噬作用。

關鍵字

交叉反應抗體；調理作用；突變株鼠傷寒桿菌

並列摘要

Successive absorption of pooled normal human serum by six strains of Salmonella typhimurium having different lipopolysaccharide composition removed strain-specific antibody and cross-reactive antibody. Cross-reactive antibody, as demonstrated by quantitative fluorescence, made some contribution to the ingestion of smooth strain (SH 2201) while anti-smooth antibody was not necessary for the opsonization of rough mutants. It was also demonstrated that anti-SR antibody (IgG) was effective in the opsonization of SR and S strains. The deposition of antibody on the surface of Ra strain was not reduced by absorption of serum by any organisms other than Ra. On the other hand, cross-reactive antibody had a small effect on the ingestion of Ra; this may be due to antibody other than IgG. Those strains ingested by neurtophils predominantly though complement activation in the presence of antibody were s, SR, and Rb2. The effect of cross-reactive antibody was none for Rb2 strain, slight for SR strain and some for s strain. It suggests that cross reactive antibody can afford immune protection though the enhancement of opsonization, especially noticeable on the ingestion of smooth strain by neurtrophils.

並列關鍵字

Cross-reactive antibody ； Opsonization ； Mutant strain ； Salmonella typhimurium

國際替代計量

Cross-Reactive Antibody in the Opsonization of Mutant Strains of Salmonella Typhimurium

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