We are here reporting a case of secondary hemochromatosis in association with thalassemia intermedia who had never received blood transfusion or iron medication in the past. The hemochromatosis may mainly result from increased iron absorption. Furthermore, hepatocellular carcinoma was highly suspected due to marked increased apha-fetoprotein and clinical manifestation in spite of no pathological evidence. The high prevalence of hepatocellular carcinoma have been showed in hemochromatosis. So early diagnosis and adequate treatment of hemochromatosis must be done in order to prevent from the development of hepatocellular carcinoma in hemochroma tosis.