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Hemochromatosis in Association with Thalassemia Intermedia

中間型地中海型貧血合併次發性血色沈著症

摘要


一位中間型地中海型貧血病人,以前從未接受輸血及鐵劑治療,三十六年後發現次發性血色沈著症,此血色沈著是腸胃道吸收鐵質增加所致。病人同時發現胎兒蛋白極度增加,雖無病理證實肝癌,但配合臨床表徵,極度懷疑肝癌。文獻報告特發性血色沈著症併發肝癌機率高。若能早期診斷及治療,可避免肝癌發生。此特提出次發性血色沈著症併發肝癌報告,以供臨床參考。

並列摘要


We are here reporting a case of secondary hemochromatosis in association with thalassemia intermedia who had never received blood transfusion or iron medication in the past. The hemochromatosis may mainly result from increased iron absorption. Furthermore, hepatocellular carcinoma was highly suspected due to marked increased apha-fetoprotein and clinical manifestation in spite of no pathological evidence. The high prevalence of hepatocellular carcinoma have been showed in hemochromatosis. So early diagnosis and adequate treatment of hemochromatosis must be done in order to prevent from the development of hepatocellular carcinoma in hemochroma tosis.

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