- 期刊
- OpenAccess
Effect of Cefodizime on Chemotaxis by Human Neutrophils
Cefodizime對人嗜中性白血球趨化作用之影響
摘要
本研究旨在探討cefodizime 對人嗜中性白血球趨化作用之影響。研究的對象包括血糖控制不好之非膜島素依賴型糖尿病病人以及年齡、性別相匹配之健康對照組各6 人。趨化作用是以fMLP作為趨化物質，以趨化指數作為評估趨化能力之依據。在沒有cefodizime先作用時，糖尿病病人嗜中性白血球之趨化指數明顯低於健康人者（分別為1.0±0.1及3.6±0.7，P＜0.0 1)，當白血球先以1 μg/ml之cefodizime作用後，cefodizime可以恢復糖尿病病人嗜中性白血球乏趨化作用（分別為1.0±0.1及2.7±0.3，P＜0.01），但不影響健康對照組者。相反地，當白血球先以100 μg/ml 之cefodizime作用後，它對糖尿病病人嗜中性白血球趨化能力並無影響，但卻抑制了健康對照組的白血球趨化作用（分別為3.6± 0.7及1.1±0.2，P＜0.01)。本研究清楚地顯示cefodizime 在較低濃度可以經由恢復嗜中性白血球之趨化能力而改善糖尿病病人之嗜中性白血球功能，同時表示cefodizime既是抗生素也是免疫修飾劑。
並列摘要
The effect of cefodizime on diabetic neutrophil funciton was demonstrated through chemotactic index. Non-insulin dependent diabetic patients with poor control (mean postprandial glucose values higher than 250 mg/dl) as well as their age- and sex-matched healthy controls were participated in this study (n=6). Chemotactic index was arrived at by finding the difference between the number of cells attracted by fMLP and the number of cells not exposed to fMLP, then dividing this difference by the number of cells not exposed to fMLP. Without cefodizime treatment, it was revealed that chemotactic index for diabetic neutrophils was significantly lower than that for healthy controls (1.0 ± 0.1 vs. 3.6 ± 0.7, p ＜ 0.01). When neutrophils were pretreated with cefodizime at 1μg/ml cefodizime restored the chemotactic activity for diabetic neutrophils (1.0 ± 0.1 vs. 2.7 ± 0.3 p＜0.01) but did not affect that for healthy controls. On the other hand, cefodizime at higher concentration (100μg/ml) had no enhancing effect on diabetic neutrophil chemotaxis, but decreased the chemotactic activity of healthy neutrophils (3.6 ± 0.7 vs. 1.1 ± 0.2, p ＜ 0.01). This study indicates that cefodizime at the level of 1μg/ml can improve diabetic neutrophil function through the enhancement of chemotaxis, suggesting that cefodizime is not only an antibiotic but also a potential immune-modulator.
延伸閱讀
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