Granulocytic Sarcoma with Spinal Cord Compression-diagnosis through Cerebrospinal Fluid (CSF) Examination

顆粒球性肉瘤合併脊髓壓迫－經腦脊髓液細胞學檢查診斷

趙祖怡(Tsu-Yi Chao) ； 陳立民(Li-Mien Chen) ； 柯萬盛(Wang-Sheng Ko) ； 黃偉修(Wei-Shou Hwang)

《Journal of Medical Sciences》 15卷2期 (1994/10) Pp. 117-124

摘要

顆粒性球肉瘤合併脊髓壓迫十分罕見，由於診斷的正確與否和病患之預後有絕對的關係，在此特提出三例報告。三例中有兩側藉著腦脊髓液細胞學及細胞化學染色之檢查得以正確診斷，在經由放射治療後神經功能得以恢復。另一例並未接受腦脊髓液檢查而直接手術，手術過後經病理切片檢查方證實為顆粒性球肉瘤，病人神經功能未能恢復。此三病例反映出腦脊髓液細胞學檢查對診斷此一疾病之重要性。

關鍵字

顆粒性球肉瘤 ； 腦脊髓液

並列摘要

Three cases of granulocytic sarcoma (GS) presented with spina1 cord compression are reported. Two of them were able to be identified by cytologica1 examination of cerebrospinal fluid (CSF), either with Wright-Giemsa stain alone or with the aid of cytochemistry studies, i.e. nonspecific esterase (NSE), chloroacetate esterase (CAE). They were successfully treated with radiotherapy with neurological functions satisfactorily preserved. The other patient was not diagnosed until tumor specimen was obtained at the time of surgica1 decompression. Neurological sequelae such as loss of anal sphincter tone, loss of muscle power and sensory functions of lower extremities greatly influenced the subsequent quality of life. The three cases illustrated the important role of cytological examination of CSF for an early recognition of GS with spina1 cord compression-a rare but troublesome disorder.

並列關鍵字

Granulocytic sarcoma ； Cerebrospinal fluid