The Effects of Human Granulocyte Colony Stimulating Factor in Allogenic Bone Marrow Transplantation: TSGH Experience

人類顆粒球細胞群落刺激因子（Filgrastim）應用於骨髓移植病患之效果－三軍總醫院臨床經驗

黃文豪(Wen-Hao Huang) ； 薛爾榮(Erh-Jueng Hsueh) ； 黃旭輝(Hsu-Huei Huang) ； 趙祖怡(Tzu-Yi Chao) ； 王成俊(Cheng-Giuen Wang) ； 張俊彥(Jang-Yang Chang)

《Journal of Medical Sciences》 16卷5期 (1996/04) Pp. 349-354

摘要

十六位血液惡性腫瘤及再生不良性貧血患者在接受相同劑量之放射線及化學治療後，接受骨髓移植，其中八位病人並接受人類顆粒球細胞群落刺激因子（rhG-CSF）之治療，而另外八位則為對照組。結果顯示可知rhG-CSF能有效縮短骨髓移植後顆粒球回升之速度、發燒時間，而降低抗生素之使用天數及醫療費用。而且其副作用小，安全性高，臨床上值得推薦。

關鍵字

骨髓移植 ； 人類顆粒球細胞群落利激因子

並列摘要

Sixteen patients with severe aplastic anemia or various types of hematological malignancy underwent allogenic bone marrow transplantation (Allogenic BMT) accompanied with and without recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy. All patients received the same conditioning regimen including total body irradiation and cyclophosphamide chemotherapy. Eight of them received rhG-CSF (400μg/m^2/day) after BMT. The duration of neutropenia,and fever were significantly shortened in the patients with rhG-CSF treatment than those without rhG-CSF treatment (p＜0.05). All the patients treated with rhG-CSF tolerated very well to the administration of rhG-CSF. The benefits of rhG-CSF are obvious.

並列關鍵字

Sixteen patients with severe aplastic anemia or various types of hematological malignancy underwent allogenic bone marrow transplantation (Allogenic BMT) accompanied with and without recombinant human granulocyte colony-stimulating factor (rhG-CSF) therapy. All patients received the same conditioning regimen including total body irradiation and cyclophosphamide chemotherapy. Eight of them received rhG-CSF (400μg/m^2/day) after BMT. The duration of neutropenia, and fever were significantly shortened in the patients with rhG-CSF treatment than those without rhG-CSF treatment (p<0.05). All the patients treated with rhG-CSF tolerated very well to the administration of rhG-CSF. The benefits of rhG-CSF are obvious.