Syphilitic ocular disorder can have a highly variable presentation and uveitis of acquired syphilis can involve the anterior or the posterior segment. We reported a 52-year-old man who developed acute and nonspecific unilateral choroiditis, vitriti s and iritis. Serologic tests including VDRL and TPHA showed positive and indicated active syphilis. The cerebrospinal fluid study showed negative. No sign of neuroretinitis was found. Secondary syphilis with panuveitis was diagnosed. Penicillin G 3.0 million units intravenously per 4 hours for two weeks was given. The inflammatory syndrome resolved and visual acuity recovered gradually thereafter. No recurrence was noted during follow-up for a period of six months.