- 期刊
- OpenAccess
Clinicopathologic Evaluation of Immunohistochemical E-Cadherin Expression in 70 Human Gastric Carcinomas
並列摘要
Background: E-cadherin plays a crucial role in cellular adhesion in epithelial tissue. The aim of this study was to investigate the role of E-cadherin in gastric tumorigenesis, cancer invasion and metastasis. Methods: E-cadherin expression was analyzed by immunohistochemistry and correlated with clinicopathological characteristics of 70 patients with gastric carcinoma. Results: Of these cases, 8 tumors (11.4%) revealed a preserved E-cadherin expression similar to that of normal gastric mucosa. Reduced E-cadherin expression was noted in 62 tumors (88.6%), while E-cadherin expression was moderately reduced in 35 tumors, and highly reduced in 27 tumors. The correlation of E-cadherin expression with histologic subtypes revealed a significantly higher frequency of reduced expression in diffuse-type and undifferentiated tumors than in intestinal type and differentiated tumors. In contrast, E-cadherin expression did not correlate with lymph node involvement, peritoneal seeding, or TNM staging and survival, although tumors with liver metastasis had relatively preserved E-cadherin expression. Conclusions: These data indicated that impaired expression of E-cadherin contributed to histogenesis and did not correlate with metastasis and poor survival in patients with gastric carcinoma.
延伸閱讀
- Zuccarello, B., Spada, A., Turiaco, N., Villari, D., Parisi, S., Francica, I., Fazzari, C., Pederiva, F., & Tovar, J. A. (2009). Intramural Ganglion Structures in Esophageal Atresia: A Morphologic and Immunohistochemical Study. International Journal of Pediatrics, 2009(), 136-142. https://doi.org/10.1155/2009/695837
- Abbasi, F., Abbasi, A., Nabizadeh, A., & Esmaili, A. (2018). Evaluation of Lymphatic Vessel Invasion by Immunohistochemistry in Breast Carcinoma. Journal of Medical Sciences, 38(5), 211-214. https://doi.org/10.4103/jmedsci.jmedsci_161_17
- 黃則達、曾志恩、黃穰基（2004）。Immunohistochemical Evaluation of the NM23-H1 Gene Product in the Oral Squamous Cell Carcinoma。慈濟醫學雜誌，16(2)，119-124。https://doi.org/10.6440/TZUCMJ.200404.0119
- Lee, W. J., Hong, R. L., Shun, C. T., Chen, C. N., & Chen, K. M. (1995). Immunohistochemical Study on the Expression of c-erbB-2 Oncoprotein in Gastric Cancer. 慈濟醫學雜誌, 7(3), 159-165. https://doi.org/10.6440/TZUCMJ.199509.0159
- Chou, K. C., Chang, L. C., Su, H. C., Lee, S. H., Lee, H. S., Lee, J. Y., Chiang, C. P., & Shieh, Y. S. (2005). Immunohistochemical Study of Tumor Angiogenesis in Mucoepidermoid Carcinoma. Journal of Medical Sciences, 25(6), 285-290. https://www.airitilibrary.com/Article/Detail?DocID=10114564-200512-201304030027-201304030027-285-290