The pedicled anterolateral thigh (ALT) flap is safe and reliable for repairing abdominal wall defects. This flap has a long pedicle and a wide arc of rotation, and it can extend from above the umbilicus and the lower back to the upper thigh, including the groin and perineum. The ALT flap is a technically simple muscle flap that permits primary closure and minimal morbidity of the donor site. We report a case of successful reconstruction of a large abdominal defect after tumor resection by using a pedicled vastus lateralis muscle flap. Literature review on the clinical applications of the ALT and pedicled vastus lateralis muscle flap for reconstruction of soft tissue defects were performed.