以低溫電漿處理對於Ti-40Nb-1Hf合金進行表面改質之研究

Study on Surface Modification of Ti-40Nb-1Hf Alloy by Low Temperature Plasma Treatment

吳恩育(En-Yu Wu) ； 馮國治(Kuo-Chih Feng) ； 潘永寧(Yung-Ning Pan) ； 李傳莉(Chuan-Li Li) ； 歐耿良(Keng-Liang Ou) ； 洪炎輝(Yen-Huei Hon)

《鑄造工程學刊》 33卷3期 (2007/09) Pp. 11-18

https://doi.org/10.29809/JTFS.200709.0002

摘要

本研究針對Ti-40Nb-1Hf合金以低溫電漿處理來進行植體表面之改質，研究方法上，首先以氬氣電漿清除鈦合金表面可能存在之微量化學污染物及雜質，然後以氧氣電漿處理，在鈦合金表面形成一緻密的氧化層，並探討氧化層之特性及其對血液相容性的影響。經電漿處理後之Ti-40Nb-1Hf合金表面形貌及氧化層特性分別以二次電子掃瞄鏡(SEM)、低掠角X光繞射儀(GIXRO)及X光電子能譜儀(XPS)進行分析。另，氧化層厚度和合金表面之潤濕性則以二次離子質譜儀(SIMS)及液滴法(sessile drop method)進行量測。此外，在體外血液相容性的實驗中，分別以凝血時間(clotting time)為指標進行分析評估。研究結果顯示，Ti-40Nb-1Hf合金經由氧氣電漿表面處理後，會形成一氧化層，此氧化層的組成主要以TiO2和Nb2O5為主，而氧化層的厚度會隨著電漿能量的增加而增加，並提升合金表面之潤濕性及血液凝固效果，進而提升鈦合金的血液相容性。此外，研究結果亦顯示，經丙烯胺(Allvfamine)電漿處理及交鏈劑戊二醛(Glutaraldehyde)的連接(crosslink)處理後，有助於白蛋白(Protein)在鈦合金表面的附著，此現象預期可以改善骨組織的癒合能力及促進骨整合。

關鍵字

Ti-40Nb-1Hf合金 ； 低溫電漿處理 ； 血液相容性

並列摘要

This study employed low temperature plasma treatment to modify the surfaces of Ti-40Nb-1Hf alloy. Firstly, argon plasma treatment is used to clean the contamination and impurity on the alloy surface, and then oxygen plasma treatment was performed to induce the formation of the oxide layer on the alloy surface. Scanning electron microscopy (SEM), grazing incident X-ray diffraction (GIXRD) and electron spectroscopy for chemical analysis (XPS) were employed to analyze the characteristics of the oxide layer formed by plasma treatment. The thickness and wettability of oxide layers on the surface of the titanium alloy were measured by secondary ion mass spectrometer (SIMS) and contact angle, respectively. In vitro study, the blood compatibility was evaluated by the parameter of clotting time. The results show that the oxide layer was formed by oxygen plasma treatment and the main compositions are TiO2 and Nb2O5. Both the thickness and surface wettability of oxide layers increase with increasing plasma power. The treated alloys have shorter clotting time, implying that the blood compatibility of the treated alloys are enhanced. In addition, after oxygen plasma treatment, some specimens were further processed by allylamine plasma treatment and crosslinking with glutaraldehyde, which exhibited increased protein adsorption. It is believed that plasma oxidation and polymerization can improve tissue healing and therefore promote osseointergration.

並列關鍵字

Ti-40Nb-1Hf alloy ； Low temperature plasma treatment ； Blood compatibility