- 期刊
Genetic Variants Susceptibility to Breast Cancer
基因變異性與乳癌的關連性
摘要
乳癌已經是臺灣婦女癌症第一位，家族遺傳性乳癌只佔5-10%，所以乳癌形成原因無法由單一基因突變解釋。乳癌的成因屬於多基因模式，是許多參與DNA修補途徑的基因，由於低穿透力基因變異型，使得DNA修補不完整。因爲若是嚴重的基因突變，細胞的DNA根本無法修補，則無法維持基因體穩定性，細胞會進行凋亡。而低穿透力基因變異性，細胞仍然有修補DNA能力，但是有些許缺陷，產生細微的基因體不穩定，細胞不會立即凋亡。經過時間累積，再加上雌激素的暴露加速DNA的損害，最終導致乳癌發生。
關鍵字
無資料並列摘要
Breast cancer is currently the leading cause of common women cancers in Taiwan. Familial breast cancer accounts for only 5-10% of all breast cancers. The breast cancer risk is likely to be explained by a polygenic model where breast cancer susceptibility is conferred by a large number of low-penetrance alleles of genes involving DNA repair pathway. The exposure to estrogen predisposes to DNA damage and mutation to become the modifying factor of breast cancer risk. The metabolites of estrogen cause DNA damage resulting in genomic instability. The subtle defect of the DNA repair pathway genes has no complete capacity for DNA repair. The accumulated DNA defects combined with environmental estrogen exposure predispose to breast tumorigenesis.
延伸閱讀
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