Deep Vein Thrombosis Associated with Marked Hyperhomocysteinemia and Active Pulmonary Tuberculosis

深層靜脈栓塞病患合併高半胱銨酸血症及急性肺結核

邱俊仁(Chiung-Zuan Chiu) ； 徐國基(Kou-Gi Shyu)

《Acta Cardiologica Sinica》 23卷3期 (2007/09) Pp. 186-191

摘要

我們報告一位32歲之慢性腎功能不全(chronic renal insufficiency)病患同時發生急性肺結核及深層靜脈栓塞合併嚴重高半胱銨酸血症，葉酸缺乏(folic acid deficiency)，及凝血功能異常。深層靜脈栓塞經heparin治療後改善。半胱銨酸指數經葉酸及維它命B12補充後回復正常。月市結核亦於藥物治療後痊癒。此篇報告中，高半胱銨酸血症是由於葉酸缺乏及慢性腎功能不全造成的。

關鍵字

深層靜脈栓塞 ； 高半胱銨酸血症 ； 肺結核 ； 葉酸缺乏 ； 高度凝血狀態

並列摘要

We report a 32-year-old male patient presented with acute deep vein thrombosis of his right leg after recent onset of active pulmonary tuberculosis. Marked hyperhomocysteinemia (＞50umol/L), folic acid deficiency, and abnormal coagulation profiles (elevations of fibrinogen and fibrinogen degradation product) were noted after a series of work-ups. After treatment with low-molecular-weight heparin, deep vein thrombosis improved. Serum homocysteine level returned to normal after folic acid and vitamin B12 supplementation for 2 months. After therapy with four-combined anti-tuberculosis drugs for 9 months, the pulmonary tuberculosis subsided. In the present case report, the cause of hyperhomocysteinemia may be related to folic acid deficiency and chronic renal insufficiency.

並列關鍵字

Deep vein thrombosis ； Hyperhomocysteinemia ； Pulmonary tuberculosis ； Folic acid deficiency ； Hypercoagulable state