- 期刊
Long-Term Prognostic Value of Mean Platelet Volume in Patients with Hypertension
摘要
Background: Although it has been shown that high mean platelet volume (MPV) is associated with target organ damage in hypertensive patients, the relationship between MPV and the development of long-term major adverse cardiovascular events (MACE) has not been thoroughly investigated. In this study, we investigated the relationship between MPV and long-term MACE in hypertensive patients. Methods: From September 2011 to July 2017, 1507 patients with hypertension were included in this study. Ambulatory blood pressure monitoring was performed in all patients. Patients with chronic renal failure, cardiovascular disease, chronic systemic disease and white coat hypertension were excluded from the study. MACE were defined as myocardial infarction, stroke and cardiovascular mortality. Patients were followed-up until january 2020. Results: The mean follow-up duration was 87 (83.3 ± 24.4) months, and 876 patients completed the study. MACE developed in 79 patients, while 797 patients were event-free. In univariate Cox regression analysis, age, diabetes mellitus (DM), MPV, creatinine, 24-hour systolic blood pressure, and non-dipper hypertension were found to be associated with the development of MACE. In multivariate Cox regression analysis, creatinine and 24-hour systolic blood pressure lost significance, and age, DM, non-dipper hypertension and MPV were found to be independent predictors for MACE development (p ＜ 0.001, p ＜ 0.001, p = 0.044, and p = 0.049, respectively). Conclusions: MPV, age, DM, and non-dipper hypertension were independent predictors of long-term MACE in hypertensive patients.
延伸閱讀
- Çetin, M., Kiziltunc, E., Elalmış, Ö. U., Çetin, Z. G., Demirçelik, M. B., Çiçekçioğlu, H., Kurtul, A., Özkan, S., Avan, C. M., Örnek, E., & Ulusoy, F. V. (2016). Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Patients with Coronary Slow Flow. Acta Cardiologica Sinica, 32(3), 307-312. https://doi.org/10.6515/ACS20150119I
- Olson, T. P., Denzer, D. L., Sinnett, W. L., Wilson, T., & Johnson, B. D. (2013). Prognostic Value of Resting Pulmonary Function in Heart Failure. Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, (2013), 35-43. https://doi.org/10.4137/CCRPM.S12525
- Guo, D. J., Zhang, K. Y. H., Chen, X. L., Chen, X. Z., Zhang, B., Zhou, Z. G., & Hu, J. K. (2015). Prognostic Value of Metastatic No.8p LNs in Patients with Gastric Cancer. Gastroenterology Research and Practice, 2015(), 784-790-206. https://doi.org/10.1155/2015/937682
- Akyüz, A., Akkoyun, D. Ç., Oran, M., DeLirmenci, H., & Alp, R. (2014). Mean Platelet Volume in Patients with Obstructive Sleep Apnea and Its Relationship with Simpler Heart Rate Derivatives. Cardiology Research and Practice, (2014), o1-7. https://doi.org/10.1155/2014/454701
- Chang, H. Y., Hsu, L. W., Lee, C. H., Lin, C. C., Huang, C. W., Chen, P. W., Yang, P. K., Hsueh, Y. C., & Liu, P. Y. (2019). Impact of Platelet Volume on the Clinical Outcomes of Patients with Acute Coronary Syndrome. Acta Cardiologica Sinica, 35(6), 563-570. https://doi.org/10.6515/ACS.201911_35(6).20190423B