- 期刊
New Biodegradable Bioceramics as a Bone Substitute: Preparation and Preliminary Evaluation
並列摘要
Although some types of ceramics such as tricalcium phosphates were reported to be resorbed in vivo, but the degradation was only superficial and partial. Searching a new biodegradable ceramic material with its basic analysis is the primary goal of this study. Ca2P2O7 was one of the intermediate products in processing of tricalcium phosphate from monocalicum phosphate. It can be resorbed slowly and shows more complete degradability under biological environment. Our new product was prepared with this raw material as the basic constituent with addition of certain amount of Na4 P2 O7•10H2O which was primarily used for intergranular liquefaction and promotion of solid state sintering. The well mixed dried slurry was sintered at 910∘C for one hour. The mechanical strength of compression and three point bending of the products were measured. The strength of the developed products will increase proportionally with the addition of Na4 P2 O7•10H2O up to 5% in weight. Preliminary in vivo evaluation was also done for the effectiveness of this new product. There was no inflammation or any toxic sign during two weeks of subcutaneous implantation. The histological section of intraosseous implantation revealed new bone depositon on the surface of the implant in the second month and the materials were gradually resorbed and replaced by the surrounding bone in the third month. The result confirms that this new product does have a great potential as an ideal biodegradable bone substitute.