The use of locking compression plate (LCP) systems in the treatment of distal radius fractures has increased during the last years. The solid purchase of bony fragment and less tissue damage have made it more popular in clinical practices. Several studies have reported complications like tendon rupture, tenosynovitis and carpal tunnel syndrome. We reported a case of rupture of extensor pollicis longus (EPL) two weeks after volar LCP fixation for distal radius fracture due to a protruding screw into the third extensor compartment of wrist. We recommend the screw should not penetrate over distal cortex of fractured fragment in correspondent holes of LCP to the third extensor compartment of wrist.