洋車前子對肥胖者體重控制與血脂質變化之臨床評估

Clinical Assessment of the Effects of Psyllium on Weight Control and the Lipid Profile of Obese Adults

盧志輝(Chih-Huei Lu) ； 李瑋婷(Wei-Ting Lee) ； 王進琦(Jinn-Chyi Wang) ； 董家堯(Jia-Yau Doong) ； 吳志忠(Chih-Chung Wu) ； 謝淑玲(Shu-Ling Hsieh)

《臺灣營養學會雜誌》 37卷4期 (2012/12) Pp. 136-146

https://doi.org/10.6691/NSJ.201212_37(4).0003

摘要

肥胖為全球重要的公共衛生問題，本研究目的為探討洋車前子（Psyllium）對體重控制與血脂質變化之影響。研究募集肥胖的成年人（身體質量指數≧27），隨機分為安慰劑組及洋車前子組。洋車前子組為每天攝取洋車前子12 g之餐前包，安慰劑組則為不含洋車前子之餐前包，試驗期間共8週，檢測受試者在餐前包介入前（第0週）及介入後第8週之體位、血液生化值與賀爾蒙的變化。研究結果顯示，無論是安慰劑組與洋車前子組，在食用餐前包8 週後，均具有降低體重、BMI、體脂肪率的效果，但兩組之間並無顯著差異（p＞0.05）。在血脂變化情形方面，洋車前子組試驗8 週後，三酸甘油酯（TG）與膽固醇（TC）含量明顯低於第0週（p＜0.05）；另一方面，無論是安慰劑組與洋車前子組，在第8週時的脂聯素濃度明顯高於第0週時，其中洋車前子組上升效果又較安慰劑組顯著，顯示洋車前子具有調節脂聯素的效果。整體而言，洋車前子的補充，可調節肥胖者之血脂值及賀爾蒙變化，可能具有降低罹患心血管疾病發生的風險，可作為日後體重控制飲食的參考。

關鍵字

洋車前子 ； 肥胖 ； 減重 ； 脂聯素

並列摘要

Obesity is a serious public health problem in numerous countries. This study describes an 8-week clinical evaluation of the effects of psyllium fiber on overweight (with a body-mass index (BMI) of ≥ 27 kg/m^2)adults in Taiwan. In this study, 74 overweight adults were recruited and randomly divided into two groups: a psyllium group (who received 12 g psyllium/day)and a placebo group(who received no psyllium). To investigate the regulatory roles of psyllium in weight control, the blood lipid profile, and hormone levels, we examined changes in body weight, body fat, fasting glucose, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol(HDL-C), leptin, and adiponectin. Results showed that both the psyllium and placebo groups exhibited significant reductions in body weight, BMI, and body fat, and there were no significant differences between the two groups. However, results of the hemobiochemical analysis showed that TG and TC decreased more significantly in the psyllium group than in the placebo group, and the results of the hormone analysis showed that adiponectin increased more significantly in the psyllium group than in the placebo group. In conclusion, psyllium supplements had the effect of regulating blood lipid profiles and hormone levels in obese people. This suggests that psyllium supplements might reduce the risk of cardiovascular disease, and be helpful in weight-control diets.

並列關鍵字

psyllium ； obesity ； weight loss ； adiponectin