The Uremic Dyslipidemia: CAPD Compare with HD

尿毒症之高血脂變化：腹膜透析與血液透析之比較

江明哲(Ming-Che Chiang) ； 楊郁(Yu Yang) ； 張家築(Cha-Chu Chang) ； 文耀閣(Yao-Ko Wen) ； 吳旭鎮(Hsu-Chen Wu) ； 康宜靜(I-Ching Kang)

《Acta Nephrologica》 15卷3期 (2001/07) Pp. 105-110

摘要

高血脂可能是造成末期腎病病人發展成心血管疾病的危險因子，為了探討末期腎病人由開始接受透析起，逐年血清白蛋白、飯前血糖、膽固醇、三酸苷油脂之變化，以及血液透析首腹膜透析患者上述四個指標的逐年差異，我們作了下列回顧性的研究。材料為我們回溯性收集從民國83年起至89年於彰化基督教醫院腎臟科接受血液透析及腹膜透析的病人共235人。其中有138人接受血液透析，97人接受腹膜透析。吾人紀錄其透析1年後、2年後、3年後、4年後、5年後其血清白蛋白、膽固醇、三酸苷油脂及空腹血糖之逐年連續變化，比較其差異，並且比較血液透析和腹膜透析患者之差異。結果發現腹膜透析組於透析一年後，血清膽固醇值即明顯增高且高於血液透析組，具統計差異。血清白蛋白於透析3年後腹膜透析組明顯低於血液透組，且具有統計差異。而血清三酸苷脂和飯前血糖值則兩組一值沒有明顯統計差異。兩組的脂質指標並不隨著透析時間的增加而更惡化。

關鍵字

末期腎病膽固醇 ； 三酸苷油脂 ； 白蛋白

並列摘要

Dyslipidemia possibly contributes to the vascular complicantions commonly afficting uremic patients. In an attempt to investigate the serial changes of serum albumin, AC sugar, cholesterol and triglyceride between HD and CAPD patients, we also try to determine the difference of these biochemical parameters in HD and CAPD patients and when the difference occur. We undertook a retrospective longitudinal study in patients start on HD and CAPD. Patients were enrolled from 1994 and their lipid profiles were annually monitored from start of dialysis until 5 years after dialysis. A total of 138 HD and 97 PD patients were studied. We examined the difference of the lipid, albumin and glucose annually between HD and PD group. Compared with HD patients, CAPD patients had significantly higher serum cholesterol levels since first year after dialysis, and significantly lower serum albumin levels since third year after dialysis. The serum a.C. glucose and triglyceride levels between two group had no significantly statistical difference with time. There was no alteration in lipids profiles with time in either group.

並列關鍵字

end-stage renal disease ； cholesterol ； triglyceride ； Albumin