Short-Term Outcome of Renal Transplantation in the Modern Era: Experience of a Single-Center in Taiwan

Ying-Chih Lo ； Hao-Chung Ho ； Ming-Ju Wu ； Cheng-Hsu Chen ； Chi-Hung Cheng ； Tung-Min Yu ； Ya-Wen Chuang ； Shih-Ting Huang ； Cheng-Kuang Yang ； Kuo-Hsiung Shu

《Acta Nephrologica》 25卷4期 (2011/12) Pp. 167-174

並列摘要

BACKGROUND: Renal transplantation provided better patient survival and quality of life than dialysis therapy. However, due to organ shortage, only few patients with end-stage renal disease had the opportunity to receive transplantation. This retrospective study aimed to analyze the outcomes of renal transplantation to elucidate the benefits and potential risks of renal transplantation. METHODS: Two hundred and forty-eight (248) renal transplant recipients at Taichung Veterans General Hospital from January 2004 and December 2008 were retrospectively studied. The clinical outcomes include biopsy-proven acute rejection, graft survival, patient survival, post-transplant diabetes mellitus and malignancy. The types of post-transplant malignancy and acute rejection were further analyzed. RESULTS: The one-year acute rejection-free rate, five-years graft survival and patient survival were 88.3%, 92.7% and 96.4%, respectively. The incidence of post-transplant diabetes mellitus and malignancy were 12.9% and 5.6%, respectively. Tumor of the genitourinary tract is the most common type of malignancy. Acute cellular rejection is the most common pathological diagnosis in patients with biopsy-proven acute rejection. The mean follow-up duration after renal transplant was 41.1 18.1 months (range, 0.5-75 months). CONCLUSION: The outcome of renal transplantation in Taiwan is comparable with that in developed countries. Routine malignancy surveillance and medical control for post-transplant diabetes mellitus is crucial to further improvement in care quality of renal transplant recipients. (Acta Nephrologica 2011; 25: 167-174)

並列關鍵字

acute rejection ； graft survival ； patient survival ； renal transplantation