- 期刊
Analysis of Renal Biopsy-Proven Renal Diseases in Geriatric Patients from a Single Center in Central Taiwan
並列摘要
Background: The elder population is growing fast as a major cause of chronic kidney disease (CKD) burden in Taiwan, however, the distribution of kidney diseases in elderly patients are not well known. The aim of this study was to compare the pattern of renal disease in elderly and control patients who underwent native renal biopsy. Methods: Among 3622 renal biopsies, excluded 588 graft biopsies and 322 inadequate criteria biopsies, we did a singlecenter, retrospective study (1992-2008) of the biopsy-proven renal diseases between geriatric patients (age≥65y/o; n=327) and control (18≤ age＜ 65; n=2385). Results: The geriatric group with mean age was 71.8±4.5 (65.1-87.3 yrs), male gender (74%), age＞70yr (n=200, 61%), the control group was 39.7±17.6(18-64.9yrs), male gender (41%). Membranous nephropathy (MN) was the most frequent diagnosis (35.8%), followed by minimal change disease/focal segmental glomerulosclerosis (MCD/FSGS) (13.1%), diabetic nephropathy (6.4%), hypertensive nephrosclerosis (5.8%),and IgA nephropathy (4.6%). Comparison with the control group showed MN to be more frequent (P ＜ 0.01), and lupus nephritis (P＜0.001) and IgAN (P＜0.001) less frequent in the elderly. However, ANCA-positive nephritis, and myeloma nephropathy and amyloid nephropathy were also more common in the elderly. Conclusions: Renal biopsy in elderly patients is a valuable diagnostic tool that should be offered the potential to modify treatment with maximal potential benefit. Age should not be considered as a contraindication to renal biopsy.
並列關鍵字
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