- 期刊
- OpenAccess
Hepatocyte Growth Factor Associates with Lower Blood Pressure and Predicts All-Cause Mortality in Hemodialysis Patients
並列摘要
AIM: Hepatocyte growth factor (HGF) is a pleiotropic cytokine. Previous studies revealed that serum HGF levels increased in kidney failure patients. Therefore, we conducted this prospective study to examine the association of HGF with other inflammatory cytokines and long-term survival in hemodialysis patients. METHODS: A total of 83 stable hemodialysis patients were recruited. The patients were divided into high (n=42) and low (n=41) HGF groups. The whole cohort was followed for the duration of 72 months. RESULTS: After a follow-up period of 72 months, 32 deaths were recorded, including 21 cardiovascular deaths. Cumulative incidence of all-cause mortality was signifi cantly higher in the high HGF group (P=0.019). Although insignifi cant, the cardiovascular mortality was also higher in the high HGF group (P=0.095). In a cox proportional hazards model, compared to low HGF group, high HGF group was found to be an independent predictor for all-cause mortality (hazard ratio 2.379; 95% CI 1.125 ~ 5.032; P=0.023), which remained signifi cant in all adjusted multivariate Cox models. Higher HGF level was found to be associated with lower blood pressure (R=0.359; P=0.001). CONCLUSION: High plasma HGF level was found to be an independent predictor of all-cause but not cardiovascular mortality in hemodialysis patients. High plasma HGF level was also associated with lower blood pressure. Further study is deserved to explore the cause and physiologic effects of elevated HGF levels.
延伸閱讀
- Liu, C. C., Lin, S. J., Hsu, Y. C., Chang, C. H., Lin, S. J., Wang, Y. Y., Li, T. C., Huang, H. C., Hsieh, Y. Y., & Lin, C. L. (2023). Association Between Physical Function Status and Mortality in Hemodialysis Patients: A Cohort Study. Acta Nephrologica, 37(2), 103-113. https://doi.org/10.6221/AN.202306_37(2).0005
- 蔡承憲、林志慶、楊五常、吳義勇（2015）。The Effect of Clinical and Genetic Factors on the Prognosis of Vascular Access in Hemodialysis Patient。腎臟與透析，27(1)，10-13。https://doi.org/10.6340/KD.2015.27(1).03
- Tsai, Y. C., Lee, C. T., Huang, T. L., Cheng, B. C., Kuo, C. C., Su, Y., Ng, H. Y., Yang, C. C., Chuang, F. R., & Liao, S. C. (2007). Inflammatory Marker but Not Adipokine Predicts Mortality among Long-Term Hemodialysis Patients. Mediators of Inflammation, 2007(), 54-58. https://doi.org/10.1155/2007/19891
- Lin, H. C., Wu, C. J., Chen, H. H., Yeh, J. C., & Tsai, C. T. (2005). Decrease in Access Blood Flow Predicts Significant Vascular Access Stenosis in Taiwanese Hemodialysis Patients. Acta Nephrologica, 19(3), 104-108. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200510-19-3-104-108-a
- 麥秀琴（2016）。Investigation of Associated Factors and Resource Utilization of Delayed Hemodialysis in End-Stage Renal Disease Patients〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-1408201602430600