Pathogenesis of Renal Injury of Coronavirus Disease 2019 Infection

Kuo-Hua Lee ； Der-Cherng Tarng

《Acta Nephrologica》 36卷1期 (2022/03) Pp. 12-19

https://doi.org/10.6221/AN.202203_36(1).0003

摘要

The coronavirus 2019 (COVID-19) pandemic has caused an enormous impact on global health and economic crisis. In addition to the typical clinical manifestations including fever, fatigue, and respiratory symptoms, a subset of patients develops acute kidney injury (AKI) following COVID-19 infection. COVID-19- associated AKI (COVID-19 AKI) results in high medical costs and serves as an independent risk factor for allcause mortality. Severe AKI requiring renal replacement therapy occurs in 5% of all hospitalized COVID-19 patients, particularly those with severe infections requiring mechanical ventilation. Despite adequate personal protective equipment, people in contact with the COVID-19 patients are at risk for getting the infection and its associated complications. Therefore, COVID-19 AKI is a critical issue that needs to be deeply understood its pathogenic mechanisms. In this review article, we summarized current evidence on the pathogenesis of renal injury of COVID-19 infection.

關鍵字

acute kidney injury ； coronavirus 2019 ； cytokine storm ； pandemic ； severe acute respiratory syndrome coronavirus 2