Chronic Systemic Inflammation Leading Eventually to Myocardial Infarction, Stroke, COPD, Renal Failure and Cancer is Induced by Multiple Risk Factors

慢性全身性發炎反應，被認為涉及多種發炎疾病如心血管疾病、中風、肺病、腎衰竭及癌症的致病機轉及其病程進展。在最近的文獻中多種危險因子，除了高膽固醇外，已被報導會引發不同器官之慢性發炎反應。目前有五種主要的危險因子可被相關的生物標記偵測出其存在與否，包括中廣型肥胖、高血脂、細菌及病毒性感染、高血糖及高半胱氨酸症。許多次要之危險因子如空氣污染、壓力、飲食及藥物等亦曾被報導。雖然這些次要的危險因子還未被高度認同，但在引發慢性發炎中仍扮演重要角色。這些次要危險因子目前還無法以專一的標記偵測出，然而有多個發炎指標如尿液微白蛋白、半胱氨酸、尿酸及硝基酪氨酸等可偵測出危險因子的存在並可追蹤治療的成功與否。

關鍵字

慢性全身性發炎反應；致命疾病；危險因子

並列摘要

Chronic systemic inflammation is implicated in the pathogenesis and progression of various inflammatory diseases including cardiovascular disease, stroke, lung diseases, renal failure and cancer. Multiple risk factors, in addition to hypercholesterolemia, have been reported in the recent literatures which are responsible for the generation of chronic inflammation in various organs. There are five major risk factors that can be identified with relative specific markers including abdominal fat, dyslipidemia, bacterial and viral infection, hyperglycemia and hyperhomocysteinemia. Many minor risk factors such as pollutant, stress, diet and drugs etc. have also been reported. Though not highly publicized these minor risk factors are also playing important role in their impact of chronic inflammation. These minor risk factors are not identified with specific markers; however, multiple inflammation markers such as urinary microalbumin, homocysteine, uric acid and 3-nitrotyrosine are useful for detecting their presence and monitoring the success of treatment.

並列關鍵字

Chronic systemic inflammation ； fatal disease ； risk factors

被引用紀錄

黃湘茹（2015）。血液透析病人發生心血管疾病相關因素之探討〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2015.01879

廖翎聿（2017）。慢性阻塞性肺病住院老人之心肺耐力相關影響因素探討〔博士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-2812201719232200

延伸閱讀

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國際替代計量

Chronic Systemic Inflammation Leading Eventually to Myocardial Infarction, Stroke, COPD, Renal Failure and Cancer is Induced by Multiple Risk Factors

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