Cyotkines, Metabolism, and Type 2 Diabetes Mellitus

第二型糖尿病(type 2 diabetes mellitus, T2DM)是常見的內分泌疾病，其致病機轉仍然未知。T2DM病患者雖然可自行分泌胰島素，但其細胞無法有效接收或傳遞胰島素的訊息而產生胰島素阻抗性(insulin resistance)；長期罹病患者的胰島素分泌能力也可能受損。許多因素可能會導致T2DM，其中以遺傳因子和環境因素最受矚目。研究可引起代謝異常的遺傳基因有助於了解糖尿病的致病因素及發展嶄新的治療與預防策略。許多研究已證實T2DM與慢性發炎反應有密切相關性，患者體內的急性發炎蛋白與細胞激素濃度都會增高。本文的主旨爲討論糖尿病的流行病學與分類，以及細胞激素在T2DM和新陳代謝中的角色。此外，本文亦納入本實驗室近年來有關T2DM病患細胞激素基因型的研究結果，提供參考。特定族群的糖尿病免疫基因學研究結果不僅有助於釐清免疫反應與T2DM的相關性，也可供發展個人化醫療與疾病預防的參考資訊。

關鍵字

細胞激素；新陳代謝；介白素；糖尿病

並列摘要

Type 2 diabetes mellitus (T2DM) is usually caused by insulin resistance, and often combined with progressive defect in insulin secretion. However, the etiology of T2DM remained unknown. Among various factors which lead to the onset of T2DM, host genetics and environmental factors are the focus of discussion. Identification and characterization of specific genes that can result in metabolic abnormalities are helpful for the effective prevention and therapeutic intervention of diabetes mellitus. Accumulating evidences have proved that T2DM is closely correlated with chronic inflammation, with increased levels of circulatory acute response proteins and cytokines in affected subjects. The aim of this article is to provide a general overview on the epidemiology, classification, and roles of cytokines in metabolism and T2DM. In addition to focusing on the cytokines-related literatures of diabetic studies, a summary of our study results concerning the polymorphisms of cytokine genes among diabetic patients is also included. Accomplishments of the immune-related genetic studies in a particular ethnic population can lead not only to the understanding of the interactions between immune responses and T2DM, but also potential clues for the designing of personalized type 2 diabetic treatment in the future.

並列關鍵字

cytokines ； metabolism ； interleukins ； diabetes

國際替代計量

Cyotkines, Metabolism, and Type 2 Diabetes Mellitus

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