A 22-year-old man with Crohn's disease was admitted to our hospital after experiencing lower abdominal pain, watery diarrhea, intermittent fever and chills for one week. There were no associated symptoms, such as nausea, vomiting, or bloody stool. Abdominal computed tomography (CT) showed mild wall thickening of remnant sigmoid colon and an 8×5 cm abscess in the pelvic region. The abscess was treated by percutaneous drainage and antibiotics. After 16 days, he was discharged and all symptoms became improved after discharge. In the present case, we demonstrated that percutaneous drainage of intra-abdominal abscess of Crohn's disease can be a safe and effective measure.