There has been no clear answer to the problem of the origin of species. Around 1850, evolution from one species to another species was overstated due to the hypotheses of natural selection, inheritance between generations and micro-mutation within a species. The structure of DNA was discovered after 1950 and sequences of genes were described around the year 2000. It has been thought that the rearrangement of genes could lead to a new species due to the fact that many of the same genes are found among various species. However, the macro-mutation between species has never been observed in multi-cellular organisms. The characteristics of creativity, care of history, future plans and religiosity, etc. in humans when compared with all other species leads to an unexplainable deep gap from the viewpoint of material structures.