- 期刊
Pharmacokinetics of Different Formulations of 2-Phenyl-4-Quinolone in Rabbit
並列摘要
The pharmacokinetics of various formulations of 2-phenyl-4-quinolone (YT -1) were evaluated in rabbits after intravenous or oral administration. A two-compartment model best described the serum YT-l concentration-time pro file after intravenous administration whereas a noncompartment model was appropriate for oral administration of the various formulations. No significant difference was found between the pharmacokinetic parameters after intravenous and oral administrations of a YT -l/citric acid formulation. Conjugates of YT-1 accounted for 86 %, 83 % and 64 % of the circulating molecules in plasma for YT -1/malic acid, YT -1 and YT -l /citric acid formulations, respectively. Comparison of the pharmacokinetics indicated significant differences of Cmax and AUC among the various dosage forms. The mean absorption of YT-l/citric acid, YT-land YT-1/malic acid formulation were 86 %,41 % and 46 % respectively, indicating that the YT-l/citric acid formulation was the best formulation prepared in this study.
延伸閱讀
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