Right-left disorientation (RLD) is not infrequently observed in neurologic patients, but its significance and lateralizing value are still uncertain. A test battery composed of four components for right-left discrimination was used to detect RLD among 46 dextral Taiwanese patients with a unilateral cerebral lesion and 52 normal subjects. The performance of the patients with left hemispheric lesions was inferior to that of controls in every component of the task. Those with right hemispheric lesions showed no difference as compared with controls. Only 56% of the normal subjects had errorless performance. Moreover, subjects with more education years had better performance. We conclude that RLD is related to a dominant hemispheric lesion and education. (Tzu Chi Med J 1996; 8: 279-284)