Optimizing the Response of Phosphodiesterase-5 Inhibitors in the Treatment of Erectile Dysfunction

口服磷酸二酯酶第五型抑制劑在治療各種原因造成的男性勃起功能障礙上，擁有很高的成功率與優良的安全性，被視為第一線的治療選擇。想要判斷對它真正無效的條件，必須先排除一些不恰當的使用方式，包括嘗試次數不足、劑量不足或缺乏性刺激。臨床上，醫師必須充分教導勃起功能障礙患者正確使用的方法，解除他們對藥物安全的恐懼，並安排門診繼續追蹤；指導服用方法時必須考量藥物間的差異，開立處方要考慮患者個別的需求。初次嘗試而反應不佳者，應該仔細詢問其使用過程，必要時調整服用劑量，並建議再重新嘗試原口服藥，這些是解決此常見問題的方法。有相當比例的患者經過這些調整措施後，可得到正面的反應結果，而避免必須接受較具侵襲性的治療選擇。

關鍵字

勃起功能障礙；再重試；磷酸二酯酣第五型抑制劑；發揮治療效果

並列摘要

Oral phosphodiesterase-5 (PDE-5) inhibitors exhibit a high success rate and good safety profile in the treatment of erectile dysfunction (ED) due to various etiologies and are regarded as first-line treatment. To define a true non-responder, one needs first to exclude inappropriate uses, such as inadequate attempts, inadequate dosing, and a lack of sexual stimulation. In clinical practice, physicians should give good instructions to patients with ED on how to use these inhibitors appropriately, relieve their phobias about the side effects of the drugs, and ensure that adequate follow-up occurs. The instructions on appropriate use should be tailored to different PDE-5 inhibitors and the individual's needs. For prior non-responders to PDE-5 inhibitors, a detailed history taking about how they used the drugs, escalating the dosage if necessary, and re-challenging with the original drug may resolve this common problem. Through these procedures, a substantial portion of non-responders will become responders and thus obviate the need for more-invasive treatments.

並列關鍵字

erectile dysfunction ； re-challenge ； phosphodiesterase-5 inhibitor ； optimizing treatment

國際替代計量

Optimizing the Response of Phosphodiesterase-5 Inhibitors in the Treatment of Erectile Dysfunction

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