Gestational Diabetes in Taiwan

Boniface J. Lin ； Jerry I. T. Huang ； Chiu-Tan Chiu

《Journal of Genetics and Molecular Biology》 5卷4期 (1994/12) Pp. 71-71

https://doi.org/10.30047/JGMB.199412.0002

並列摘要

Non-insulin-dependent diabetes mellitus (NIDDM) is thought to develop gradually over the course of many decades, punctuated by periods of exacerbation caused by infections and pregnancies. A recent survey indicated that the prevalence rate of NIDDM among women aged 40 years and over is about 9% in Taipei City. It is, therefore, interesting to investigate the prevalence rate of gestational diabetes mellitus (GDM), a possible precursor of NIDDM, and follow up these patients for decades to come.
During two years following Aug. 1, 1990, we screened 6154 women with 50 g of glucose administered orally during 24th to 28th weeks of gestation. They were not required to fast for this screening test. One hour after glucose administration, the plasma glucose levels of 4010 women (65.2%) were below 130 mg/dl. In the remaining 2144 women (34.8%) whose plasma glucose levels were over 130 mg/dl, 1527 women (24.8%) showed levels over 140 mg/dl. Those who had a screening plasma glucose level of over 130 mg/dl were administered a modified 75 g oral glucose tolerance test for three hours after consuming at least 150 g of carbohydrate daily for three days. Plasma samples were collected hourly for 3 hours. There were 265 women (4.3% of all women screened) whose plasma glucose levels 2 h after glucose challenge ranged between 140 and 199 mg/dl. A small but significant number (6.5%) of these patients with impaired glucose tolerance (IGT) gave birth to babies weighing over 4 kg. The approximate prevalence rate of giant babies among all newborn babies in our hospital is 3%. O’Sullivan and Mahan’s criteria were applied to our data, and 145 women, or 2.4% of all those screened, fitted the diagnosis of GDM. The prevalence rate of giant babies was 9.7% in these GDM patients. Among 617 women whose screening plasma glucose levels ranged between 130 and 139 mg/dl, there were 29 IGT women (0.5%) and 4 GDM women (0.1%). These GDM patients gave birth to 1 giant baby, but the IGT women, none. Of the 1527 women whose screening plasma glucose levels were over 140 mg/dl, 236 (3.8%) turned out to be IGT and 141 (2.3%) GDM. Cesarean section was in all pregnant women in our hospital is 27%.