Necrotizing Pneumonia Associated with Septicemia Caused by Clostridium perfringens: A Case Report

產氣莢膜梭菌導致菌血症合併壞死性肺炎：個案報告

陳昶華(Chang-Hua Chen) ； 何上芸(Shang-Yun Ho) ； 林楷煌(Kai-Huang Lin)

《內科學誌》 22卷4期 (2011/08) Pp. 287-291

https://doi.org/10.6314/JIMT.2011.22(4).08

摘要

產氣莢膜梭菌(Clostridium perfringens)通常感染惡性腫瘤或是創傷的病患，感染後有可能導致嚴重的感染。我們報告一個病例健康65歲男性病患，罹患產氣莢膜梭菌導致菌血症合併壞死性肺炎，最初臨床表現是發熱，休克，與呼吸窘迫。使用有效的抗生素及即時的支持治療，病患恢復健康。這位病患是產氣莢膜梭菌導致生菌血症與肺炎併發休克。在回顧世界文獻並且分析產氣莢膜梭菌相關性壞死性肺炎的案例進行分析，整體而言，產氣莢膜梭菌感染引起的死亡率爲50%。產氣莢膜梭菌感染在高風險病患，如果沒有及時治療會發生極高的死亡率和併發症。

並列摘要

Clostridium perfringens (C. perfringenes) usually infects patients with trauma and malignancy, and may cause severe infections. We report a case of necrotizing pneumonia complicated with septic shock due to C. perfringenes in a 65-year-old immunocompetent male without preceding trauma or malignancy. He presented febrile, shock and respiratory distress initially. He recovered after treatment with effective antibiotics and supportive care. Our patient who developed bacteremic pneumonia complicated with septic shock illustrates the pathogenic potential of C. perfringenes in an immunocompetent host. C. perfringenes related necrotizing pneumonia related with a 50% mortality rate was demonstrated. Infections caused by C. perfringenes are associated with high risk of mortality and morbidity if antibiotic therapy is not timely prescribed.

並列關鍵字

Necrotizing pneumonia ； Septicemia ； Clostridium perfringens ； Immunocompetent