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Adrenal Adenoma Removal Improves Glucose Control in a Diabetic Patient with Primary Aldosteronism: A Case Report and Literature Review

原發性高醛固酮症的糖尿病患者在接受手術移除腎上腺皮質腺瘤後血糖控制的改善-病例報告及文獻回顧

摘要


原發性高醛固酮症是造成次發性高血壓的常見原因,但此疾病與葡萄糖代謝異常的相關聯性卻很常被忽略。我們報告一位患有醛固酮分泌腺瘤併頑固性高血壓及低血鉀的糖尿病患者,在接受腫瘤切除手術之後,除了血壓與血鉀恢復正常之外,血糖亦趨近於正常,且後續追蹤時再也無須接受藥物治療。手術切除醛固酮分泌腺瘤對於改善此種獨特糖尿病亞型的血糖控制有其重要臨床意義,及時的診斷與治療將使病人免於不必要的終身藥物治療及糖尿病的相關併發症。

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並列摘要


Primary aldosteronism (PA) is a common etiology of secondary hypertension but its association with impaired glucose homeostasis is often overlooked. In this article, we report on the case of a diabetic patient with refractory hypertension, who was later diagnosed with an aldosterone-producing adenoma (APA). Surgical resection of the APA rectified his hypertension and hypokalemia and restored his blood sugar level to near normal range. Since surgery, he has not been administered any oral hypoglycemic agents but has still remained free from diabetes. Better blood sugar control following APA resection in this unique group of diabetic patients is of clinical importance since early diagnosis and surgical treatment can prevent the unnecessary life-long administration of medication and the occurrence of diabetes-associated complications.

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