中醫藥對成人原發性IgA腎炎的療效研究

The Therapeutic Effect of Chinese Medicine on Primary Adult IgA Nephritis

鍾國俊(Kuo-Chun Chung)

《中醫藥雜誌》 7卷2期 (1996/06) Pp. 101-118

https://doi.org/10.6940/JCM.199606_7(2).03

摘要

IgA nephritis, discovered by Berger and Hinglais in 1968, is considered to be the most common nephritis in the world. This disease is not benign as it was considered to be at first. In about 15-20%, even 25-40%, of cases, renal failure develops 5-10 years after the first episode, and the patients need supportive dialysis.
Western medicine still has no effective treatment for this disease. Although the real pathogenic mechanism of IgA nephritis is not c1ear, it is identified as one kind of immunocomplex disease. Chinese medicine is known to regu1ate the abnormal immune function of the human body, and hence there is gocd motive for investigating Chinese medical treatment as a therapeutic solution.
Thirty-two cases of the primary IgA nephritis patients identified through kidney biopsies as Class Ⅲ were selected in this research. Of the total, 24 were males and 8 females, and 30 were under the age of 40. IgA nephritis patients have hematuria, which provides a basis in Chinese medicine for identifying patterns and determining treamtent (bian zheng lun zhi), and the therapeutic effect can be evaluated by modem laboratory tests.
The results show that Chinese medical therapy improved clinical symptoms and signs markedly. It was effective for hematuria in 89.3% of cases, and for proteinuria in 86.7% of cases. It brought biochemical function back to normal. The reduction in the IgA concentration in the blood and hypertension was biostatistically significant (p＜0.001). Chinese medical therapy for adult primary IgA nephritis is effective. Further basic research is needed to understand the mechanisms.

關鍵字

原發性IgA腎炎 ； 辨證論治

並列摘要

IgA nephritis, discovered by Berger and Hinglais in 1968, is considered to be the most common nephritis in the world. This disease is not benign as it was considered to be at first. In about 15-20%, even 25-40%, of cases, renal failure develops 5-10 years after the first episode, and the patients need supportive dialysis.
Western medicine still has no effective treatment for this disease. Although the real pathogenic mechanism of IgA nephritis is not c1ear, it is identified as one kind of immunocomplex disease. Chinese medicine is known to regu1ate the abnormal immune function of the human body, and hence there is gocd motive for investigating Chinese medical treatment as a therapeutic solution.
Thirty-two cases of the primary IgA nephritis patients identified through kidney biopsies as Class Ⅲ were selected in this research. Of the total, 24 were males and 8 females, and 30 were under the age of 40. IgA nephritis patients have hematuria, which provides a basis in Chinese medicine for identifying patterns and determining treamtent (bian zheng lun zhi), and the therapeutic effect can be evaluated by modem laboratory tests.
The results show that Chinese medical therapy improved clinical symptoms and signs markedly. It was effective for hematuria in 89.3% of cases, and for proteinuria in 86.7% of cases. It brought biochemical function back to normal. The reduction in the IgA concentration in the blood and hypertension was biostatistically significant (p＜0.001). Chinese medical therapy for adult primary IgA nephritis is effective. Further basic research is needed to understand the mechanisms.

並列關鍵字

Primary IgA nephritis ； Identifying patterns and determining treamtent