神經管胚細胞瘤之治療

Treatment of Medulloblastoma

陳麗惠(L. H. Chen) ； 林芳仁(F. J. Lin)

《中華放射線醫學雜誌》 16卷2期 (1991/06) Pp. 113-119

摘要

A total of 32 patients with biopsy-proven medulloblastoma were treated at Department of Radiation Oncology, Chang Gung Memorial Hospital from May 1979 through Feb. 1987. Cranio-spinal axis irradiation was given following surgical resection. The median follow-up was 67 months. The overall 5- and 10-year actuarial survival rates were 53% and 50% respectively. The median time of recurrence was 14 months. Males had a lower 5-year actuarial survival rate than females (39% vs. 71%, P＜0.05). Patients with early-stage tumors (T1 & T2) had a higher 5-year survival rate than those with late-stage tumors (T3 & T4), although the difference was not statistically significant (65% vs. 33%, P＞0.05).
The 5-year survival rate was significantly higher (P＜0.05) in patients who received 30Gy or more to the cranio-spinal axis and also 50Gy or more to the posterior fossa than in those who received a lower dose.
The extent of surgery had no impact on prognosis. Patients older than 15 years of age had a higher 5-year survival rate, but this factor might not be independent. All spinal relapse occurred in patients who didn't receive radiotherapy of spinal axis. Frontal lobe was another important site of relapse and needed special attendance in treatment planning.

關鍵字

神經管胚細胞瘤 ； 放射線治療 ； 預後

並列摘要

A total of 32 patients with biopsy-proven medulloblastoma were treated at Department of Radiation Oncology, Chang Gung Memorial Hospital from May 1979 through Feb. 1987. Cranio-spinal axis irradiation was given following surgical resection. The median follow-up was 67 months. The overall 5- and 10-year actuarial survival rates were 53% and 50% respectively. The median time of recurrence was 14 months. Males had a lower 5-year actuarial survival rate than females (39% vs. 71%, P＜0.05). Patients with early-stage tumors (T1 & T2) had a higher 5-year survival rate than those with late-stage tumors (T3 & T4), although the difference was not statistically significant (65% vs. 33%, P＞0.05).
The 5-year survival rate was significantly higher (P＜0.05) in patients who received 30Gy or more to the cranio-spinal axis and also 50Gy or more to the posterior fossa than in those who received a lower dose.
The extent of surgery had no impact on prognosis. Patients older than 15 years of age had a higher 5-year survival rate, but this factor might not be independent. All spinal relapse occurred in patients who didn't receive radiotherapy of spinal axis. Frontal lobe was another important site of relapse and needed special attendance in treatment planning.

並列關鍵字

medulloblastoma ； radiation therapy ； prognosis