Mesenchymal hamartoma of the liver (MHL) is an oncological entity occurs almost exclusively in infancy and childhood. Fewer than 200cases have been reported. We present a case of a 7-month-old female infant, who was admitted to our institution with abdominal distension. Computed tomography (CT) showed a 12-cm multiloculated mass in the left lobe of liver. Angiography demonstrated a hypovascular mass with stretching of the left intrahepatic vessels. The patient underwent surgical enucleation of the tumor. The pathological report confirmed a mesenchymal hamartoma of the liver. There had been a long time since the heat of the 90’s related to hamartomatous lesions of the liver. Little reports in the radiological field were announced ever since.