奈米科技在分子生物學已造成革命性的影響,特別是在分子與細胞層級的診斷與治療上,結合了奈米科技、生物化學及光電工程,開啟了偵測分子及原子的可能性,在細胞層級的醫藥研究將有相當大的應用潛能,許多研究群均朝此方面努力。本文簡介了生醫感測系統原理、國內外應用奈米材料應用於生物醫學的分析原理及各式奈米粒子的化學表面修飾。
The development of nanotechnology has imposed profound impact on the biomedical detection and diagnosis. The combination of nanoscience, biochemistry and photonics has made it possible to detect and monitor biomarkers at the molecular and even atomic level, and subsequently bring diverse potential application targeting on cellular medicine research and development. The major theme of this article is to overview the fundamental principles of biomedical sensing, including the surface modification of nanoparticles, nano-material development, and the detection mechanisms.