磁性奈米粒子於生醫領域之應用

Biomedical Application of Magnetic Nanoparticles: Principles and Current Developments

李昆峰(Kun-Feng Lee) ； 高肇鴻(Chao-Hung Kao) ； 陳錚誼(Cheng-Yi Chen) ； 趙啟民(Chi-Min Chau) ； 卓慧如(Hui-Ju Cho) ； 林玉娟(Yuh-Jiuan Lin)

《科儀新知》 153期 (2006/08) Pp. 61-69

https://doi.org/10.29662/IT.200608.0006

摘要

由於磁性奈米粒子所具有之獨特性質，例如超順磁性、高飽和磁化量與高有效表面積等，因此已被應用於生物醫學診斷造影、疾病治療及生化分離等生醫領域。生物醫學診斷造影方面主要是作為提高影像對比之顯影劑及標定特定標的之追蹤劑；疾病治療方面可作為藥物輸送之載體或者是利用外加磁場，使注入體內的磁性奈米微粒產生熱能，以殺死癌細胞，改善傳統化療方式對正常細胞的傷害；生化分離方面則是利用經表面修飾之磁性奈米粒子與目標物質接合，在磁場作用下，可有效率的將微量目標物質從複雜的混合物中分離，得到純度高的物質，不致破壞生物物質之活性，可免除使用過濾、層析與離心等複雜的分離方法。在本文中筆者將針對磁性奈米粒子在生醫應用上之發展現況加以介紹。

並列摘要

Magnetic nanoparticles have been utilized for biomedical purpose due to their unique features such as its superparamagnetism, high saturation magnetization and high effective surface areas, etc. In diagnosis aspect, magnetic nanoparticles can be used as contrast agents for magnetic resonance imaging, and as labels for biomedical sensing. On the other hand, they have attracted attention in disease therapies because of their potential as carriers for site-specific drug delivery and heating mediators for hyperthermia. However, the bio-separation is also an important in vitro application of magnetic nanoparticles. In this article, the development of variety of biomedical application including biomedical diagnosis imaging, disease therapies, bio-separation and biosensing were introduced.