電噴灑輔助雷射脫附游離質譜儀

Electrospray-Assisted Laser Desorption Ionization Mass Spectrometry

謝建台(Jentaie Shiea)

《科儀新知》 168期 (2009/02) Pp. 61-68

https://doi.org/10.29662/IT.200902.0006

摘要

電噴灑輔助雷射脫附游離法是一種結合電噴灑游離法及雷射脫附游離法的新式大氣壓力游離法。電噴灑輔助雷射脫附游離質譜儀主要由雷射、電噴灑系統、樣品平台及質量分析器所組成，其原理為利用高能雷射將樣品表面之化學物種脫附，再使脫附之分析物分子與由電噴灑游離所產生之帶電溶劑液滴反應，形成帶單價或是多價電荷之分析物離子。此儀器可在不需任何樣品前處理下，直接且快速地分析各種固體及液體樣品表面上之化學組成物質。

並列摘要

Electrospray-assisted laser desorption ionization (ELDI), a combination of electrospray ionization and laser desorption, is an ambient ionization source developerd in our laboratory. ELDI MS is consisted of a laser set, electrospray system, sampling platform and mass analyzer. The principle of this instrument is to laser desorb the chemicals from the surface of sold or liquid; the desorbed molecules are then post-ionized in an ESI plume to form singly or multiply charged ions; these ions are subsequently detected by the mass analyzer attached to the source. Sample pretreatment in ELDI MS analysis is minimum or unnecessary.