- 期刊
- OpenAccess
液態核磁共振光譜技術在蛋白質藥物設計之運用
Application of Solution NMR in Protein Drug Design
摘要
近年來蛋白質藥物已漸漸地使用在許多疾病的治療上，這樣的趨勢顯示蛋白質藥物在藥物開發上扮演極重要的角色。為了設計具有生物功能性的蛋白質來當作藥物，我們必須對其蛋白質結構與其受體在結合時的作用有完整清楚的瞭解，而核磁共振光譜具有獨特的能力，可以獲得溶液狀態下蛋白質結構以及蛋白質與標的蛋白質交互作用間的資訊，目前已有許多核磁共振光譜技術運用到蛋白質藥物的研究，並確認它們與其標的蛋白質間的作用模式，筆者將在本文中介紹這些技術，以及如何運用它們來獲取重要資訊，俾設計蛋白質藥物。
關鍵字
無資料並列摘要
During recent years, protein therapeutics are increasingly used for the treatment of many diseases. This trend lights on the significant role of protein drugs in the development of drugs. To facilitate the applications of biologically functional protein in drug design, it is necessary to have a thorough understanding of their conformations and their interactions with the receptors. NMR spectroscopy has the unique ability to retrieve information about 3D structures of proteins and their interactions with the target proteins in solution. Many NMR techniques have been used to study a number of pharmaceutically important proteins and characterize their interactions with the targets. In this review, we will introduce these NMR methods and show how to utilize them for protein drug design.
並列關鍵字
無資料延伸閱讀
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